I don't much worry about my garbage's comfort.
Though, I have found fish tend to die if you leave them in the transport bag too long. I can only imagine that's uncomfortable.
If I don't sleep well I get bags under my eyes. Seems they are bigger at warmer temperatures. Sample size is small on this one as I get good sleep.
And generally I don't care what temperature it is if someone hits me front-on while I'm driving; I want those airbags to deploy despite knowing it's about to get real uncomfortable.