I'm 6'2" and 190#. I have a Shad comfort seat on mine, but I only have the Shad seat installed, I took the pillon off and put the stock one back on to make more room in the saddle. I leveled the seat (check for "seat slope mod"). I also installed 30mm handlebar risers, and a set of highway pegs. Then adjusted everything to where it felt comfortable.
I have done 500 mile days on it, and not felt too bad. It helps to have the highway pegs just to give yourself a change of position. They do make drop pegs for the NC, but I am looking for wider, longer and more aggressive. If it also happens to have a drop version I would probably do that too.
Everyone is different, but hopefully my experiences will translate a little, and give you a starting point. If you get to Colorado, let me know and you can try mine for size.