I rode about 150 miles without stopping, coming down from Los Alamos. About 70 mph. But I wasn't comfortable for portions of the ride.
While my Puig windscreen and windscreen attachment help keep the wind blast from its worst there can be some noise from any sidewinds. Enough to where I try to wear earplugs, which I find uncomfortable. I tried Eargasms but they have a hard center filter. While effective they began to irritate after about 50 miles of riding. But this could be an issue with any motorcycle.
The main thing I've noticed is that like a lot of riders, to get comfortable, the bars need to go up and back a little. I had a friend take photos of me from the side, mounted up, ready to ride and my posture was just not correct. Too hunched forward. To get in a proper position we figured my hands needs to be about 2 inches closer and a little higher than where my grips are now. This is why when I go on longer rides I'm constantly moving around, trying to stretch to ease the discomfort. So risers might help.
Same thing with my legs. I tend to not keep my toes on the pegs and move my feet further forward. I think it might be help if I lower the pegs. Or maybe raise the seat with of those expensive air pads. Not sure if I want to add the weight of bars and front cruiser highway pegs.
One thing that really helps is a new seat, and this is the case with any non-touring bike, for lots of riders. I got the Sargent seat and have no butt issues.
MY bike has a vibration that starts at exactly 71 mph in 6th gear, so might consider changing the front or rear sprocket to see if I can lower the rpms enough where it would be smooth at that commonly-driven speed. This could be the only thing that is really my bike's fault, as other riders, of different sizes and builds, might not have the same comfort issues.
But generally, with all bikes including the NC, for distance riding you need to change the stock windscreens and seat. If you don't it's probably because you are exactly the same size, shape and build as the motorcycle company's test riders!